Design, synthesis and activity evaluation of arctigenin derivatives with HDAC inhibition activity-Reference-Cited by-同舟云学术

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Design, synthesis and activity evaluation of arctigenin derivatives with HDAC inhibition activity

Published:2024 Issue:13 Volume:14 Page:9314-9325
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Jiang Xinyue¹,Yan Yuchao¹,Yang Huali¹,Cheng Maosheng¹^ORCID,Dou Deqiang²,Liu Yang¹^ORCID

Affiliation:

1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China

2. Department of Chinese Medicine Chemistry, Liaoning University of Traditional Chinese Medicine, Dalian, 116000, P.R. China

Abstract

This study demonstrated that an arctigenin derivative B7 induced apoptosis in leukemia MV411 cells by enhancing histone acetylation levels and activating the Caspase-3 pathway.

Funder

National Natural Science Foundation of China

Program for Liaoning Innovative Talents in University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00050A

Reference23 articles.

1. Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy

2. Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM

3. Mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines

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