Daidzein alleviates doxorubicin-induced heart failure <i>via</i> the SIRT3/FOXO3a signaling pathway-Reference-Cited by-同舟云学术

Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway

Published:2022 Issue:18 Volume:13 Page:9576-9588
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Huaxin¹,Zhang Mengxue¹,Wang Yuanyu²,Gong Ke¹,Yan Tengteng¹,Wang Dandan³,Meng Xianshe¹,Yang Xiaoxiao¹^ORCID,Chen Yuanli¹^ORCID,Han Jihong¹⁴,Duan Yajun¹⁵^ORCID,Zhang Shuang¹^ORCID

Affiliation:

1. Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China

2. Beijing Institute of Biomedicine, Beijing, China

3. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China

4. College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China

5. Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China

Abstract

Daidzein improves doxorubicin-induced heart failure in mice by activating AMPKα and SIRT3/FOXO3a pathway-mediated energy balance and improving mitochondrial function, thereby inhibiting inflammation, fibrosis, apoptosis, oxidative stress in heart.

Funder

Tianjin Science and Technology Committee

National Natural Science Foundation of China

Central University Basic Research Fund of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO00772J

Reference54 articles.

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