Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite-Reference-Cited by-同舟云学术

Deciphering the chemical instability of sphaeropsidin A under physiological conditions – degradation studies and structural elucidation of the major metabolite

Published:2020 Issue:40 Volume:18 Page:8147-8160
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

van der Westhuyzen Alet E.¹²³⁴⁵,Ingels Aude⁶⁷⁸⁹¹⁰,Rosière Rémi⁶⁷⁸⁹^ORCID,Amighi Karim⁶⁷⁸⁹,Oberer Lukas¹¹¹²¹³¹⁴^ORCID,Gustafson Kirk R.¹⁵¹⁶¹⁷¹⁸¹⁹^ORCID,Wang Dongdong¹⁵¹⁶¹⁷¹⁸¹⁹^ORCID,Evidente Antonio²⁰²¹²²²³^ORCID,Maddau Lucia²⁴²⁵²⁶²⁷²³^ORCID,Masi Marco²⁰²¹²²²³^ORCID,de Villiers André¹²³⁴⁵^ORCID,Green Ivan R.¹²³⁴⁵^ORCID,Berger Walter²⁸²⁹³⁰³¹³²^ORCID,Kornienko Alexander³³³⁴³⁵¹⁹^ORCID,Mathieu Veronique⁶⁷⁸⁹¹⁰,van Otterlo Willem A. L.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Polymer Science

2. University of Stellenbosch

3. Matieland

4. Stellenbosch

5. South Africa

6. Department of Pharmacotherapy and Pharmaceutics

7. Université libre de Bruxelles (ULB)

8. 1050 Ixelles

9. Belgium

10. ULB Cancer Research Center

11. Novartis Institutes for BioMedical Research

12. Global Discovery Chemistry

13. Basel

14. Switzerland

15. Molecular Targets Program

16. Center for Cancer Research

17. National Cancer Institute

18. Frederick

19. USA

20. Department of Chemical Sciences

21. University of Naples Federico II

22. 80126 Naples

23. Italy

24. Department of Agriculture

25. Section of Plant Pathology and Entomology

26. University of Sassari

27. Sassari

28. Department of Medicine I

29. Institute of Cancer Research and Comprehensive Cancer Center

30. Medical University of Vienna

31. Vienna

32. Austria

33. Department of Chemistry and Biochemistry

34. Texas State University

35. San Marcos

Abstract

The degradation of the fungal metabolite sphaeropsidin A, under physiological conditions, was investigated and the structure of the major degradation product determined.

Funder

National Research Foundation

Universiteit Stellenbosch

Department of Science and Technology, Republic of South Africa

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01586E

Reference46 articles.

1. Bioactive Metabolites from Pathogenic and Endophytic Fungi of Forest Trees

2. Pimarane diterpenes: Natural source, stereochemical configuration, and biological activity

3. A phytotoxic pimarane diterpene of Sphaeropsis sapinea f. sp. Cupressi, the pathogen of a canker disease of cypress

4. Evaluation of in vitro anticancer activity of sphaeropsidins A–C, fungal rearranged pimarane diterpenes, and semisynthetic derivatives

5. Further secondary metabolites produced by Diplodia corticola, a fungal pathogen involved in cork oak decline