Co-crystallization and polymorphic behaviour of 5-fluorouracil-Reference-Cited by-同舟云学术

Co-crystallization and polymorphic behaviour of 5-fluorouracil

Published:2019 Issue:13 Volume:21 Page:2130-2134
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Enkelmann Dennis D.¹²³⁴,Handelmann Jens⁵⁶⁷⁸⁹,Schauerte Carsten¹⁰¹¹⁹,Merz Klaus⁵⁶⁷⁸⁹^ORCID

Affiliation:

1. Institute of Pharmacy

2. University of Innsbruck

3. 6020 Innsbruck

4. Austria

5. Inorganic Chemistry I – Bioinorganic Chemistry

6. Faculty of Chemistry and Biochemistry

7. Ruhr University Bochum

8. 44797 Bochum

9. Germany

10. Solid-Chem GmbH

11. 44799 Bochum

Abstract

Hydrogen donors and acceptors in 5-fluorouracil allow the formation of co-crystalline compounds with nontoxic co-formers of the GRAS list and an alternative target-oriented synthon approach from methanol or ethanol to form II of 5-fluorouracil is presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CE/C8CE01692E

Reference20 articles.

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2. Pharmaceutical cocrystals: walking the talk

3. The A to Z of pharmaceutical cocrystals: a decade of fast-moving new science and patents

4. Drugs and the pharmaceutical sciences, Polymorphism in pharmaceutical solids , ed. H. G. Brittain , 2nd edn, 2009 , p. S. 76

5. High-pressure recrystallisation—a route to new polymorphs and solvates

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