In silico study of PEI-PEG-squalene-dsDNA polyplex formation: the delicate role of the PEG length in the binding of PEI to DNA-Reference-Cited by-同舟云学术

In silico study of PEI-PEG-squalene-dsDNA polyplex formation: the delicate role of the PEG length in the binding of PEI to DNA

Published:2021 Issue:19 Volume:9 Page:6623-6640
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Vasiliu Tudor¹,Craciun Bogdan Florin¹^ORCID,Neamtu Andrei²,Clima Lilia¹,Isac Dragos Lucian¹,Maier Stelian S.¹³,Pinteala Mariana¹^ORCID,Mocci Francesca¹⁴^ORCID,Laaksonen Aatto¹⁵⁶⁷^ORCID

Affiliation:

1. Center of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, Iasi 700487, Romania

2. Bioinformatics Laboratory, TRANSCEND IRO, Iaşi 700843, Romania

3. Polymers Research Center, “Gheorghe Asachi” Technical University of Iasi, Iasi, 700487, Romania

4. Dipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Monserrato, 09042 Cagliari, Italy

5. Department of Materials and Environmental Chemistry, Division of Physical Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden

6. State Key Laboratory of Materials-Oriented and Chemical Engineering, Nanjing Tech University, 210009 Nanjing, PR China

7. Department of Engineering Sciences and Mathematics, Division of Energy Science, Luleå University of Technology, 97187 Luleå, Sweden

Abstract

Using a two step simulation protocol the atomistic interactions between PEG and b-PEI and the effect of these interactions on DNA binding were determined.

Funder

Vetenskapsrådet

Autoritatea Natională pentru Cercetare Stiintifică

Ministerul Cercetării şi Inovării

Regione Autonoma della Sardegna

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00973G

Reference68 articles.

1. Gene therapies development: slow progress and promising prospect

2. D. A.Bleijs , Gene Therapy Net 2019 [cited 2020 2]. Available from: http://www.genetherapynet.com/gene-therapy-products-on-the-market.html

3. Gene Therapy Using Adeno-Associated Virus Vectors

4. P.Neuberg and A.Kichler , Recent developments in nucleic acid delivery with polyethylenimines , in Advances in genetics , Elsevier , 2014 , vol. 88 , pp. 263–288

5. Cationic polymers for non-viral gene delivery to human T cells

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. PEI‐Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa;Advanced Healthcare Materials;2024-09-11

2. Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility;Drug Delivery;2024-08-17

3. Molecular Modeling in Drug Delivery: Polymer Protective Coatings as Case Study;Exploring Computational Pharmaceutics ‐ AI and Modeling in Pharma 4.0;2024-06-21

4. PEI-based functional materials: Fabrication techniques, properties, and biomedical applications;Advances in Colloid and Interface Science;2024-03

5. Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine;Polymers;2023-10-25