Model development for enzymatic reactive crystallization of β-lactam antibiotics: a reaction–diffusion-crystallization approach-Reference-Cited by-同舟云学术

Model development for enzymatic reactive crystallization of β-lactam antibiotics: a reaction–diffusion-crystallization approach

Published:2020 Issue:11 Volume:5 Page:2064-2080
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Salami Hossein¹²³⁴^ORCID,Lagerman Colton E.¹²³⁴,Harris Patrick R.¹²³⁴^ORCID,McDonald Matthew A.¹²³⁴,Bommarius Andreas S.¹²³⁴^ORCID,Rousseau Ronald W.¹²³⁴^ORCID,Grover Martha A.¹²³⁴^ORCID

Affiliation:

1. School of Chemical and Biomolecular Engineering

2. Georgia Institute of Technology

3. Atlanta

4. USA

Abstract

A mathematical model for production of β-lactam antibiotics via enzymatic reactive crystallization is developed, and its application for catalyst and process design is discussed.

Funder

U.S. Food and Drug Administration

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/D0RE00276C

Reference51 articles.

1. The enzymes of β-lactam biosynthesis

2. Kinetics of β-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization