Inverted strand polarity yields thermodynamically stable G-quadruplexes and prevents duplex formation within extended DNA-Reference-Cited by-同舟云学术

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Inverted strand polarity yields thermodynamically stable G-quadruplexes and prevents duplex formation within extended DNA

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chilton Bruce¹^ORCID,Roach Ruby J.¹^ORCID,Edwards Patrick J. B.¹^ORCID,Jameson Geoffrey B.¹^ORCID,Hale Tracy K.¹^ORCID,Filichev Vyacheslav V.¹^ORCID

Affiliation:

1. School of Food Technology and Natural Sciences, Massey University, Private Bag 11-222, Palmerston North 4442, New Zealand

Abstract

Telomeric DNA strands with inverted sequence polarity form stable G-quadruplexes (G4s) even in the presence of complementary DNA and interact with G4-binding domain of Heterochromatin Protein 1α.

Funder

Australian Institute of Nuclear Science and Engineering

Health Research Council of New Zealand

Massey University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05432B

Reference38 articles.

1. High-throughput sequencing of DNA G-quadruplex structures in the human genome

2. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

3. Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

4. The application of DNA and RNA G-quadruplexes to therapeutic medicines

5. Molecular Engineering of Guanine-Rich Sequences: Z-DNA, DNA Triplexes, and G-Quadruplexes

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