Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors-Reference-Cited by-同舟云学术

Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors

Published:2016 Issue:26 Volume:14 Page:6304-6315
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Trinh Trieu N.¹²³⁴⁵,McLaughlin Eileen A.⁶²³⁴⁵^ORCID,Abdel-Hamid Mohammed K.¹²³⁴⁵,Gordon Christopher P.⁷⁸⁹¹⁰⁵,Bernstein Ilana R.⁶²³⁴⁵,Pye Victoria⁶²³⁴⁵,Cossar Peter¹²³⁴⁵,Sakoff Jennette A.¹¹¹²¹³⁵,McCluskey Adam¹²³⁴⁵

Affiliation:

1. Chemistry

2. Priority Research Centre for Chemical Biology

3. University of Newcastle

4. Callaghan

5. Australia

6. Biology

7. Nanoscale Organization and Dynamics Group

8. School of Science and Health

9. University of Western Sydney

10. Penrith South DC

11. Department of Medical Oncology

12. Calvary Mater Hospital

13. Waratah

Abstract

A series of quinolone-2-(1H)-ones derived from a Ugi-Knoevenagel three- and four-component reaction were prepared exhibiting low micromolar cytotoxicity against a panel of eight human cancer cell lines known to possess the Hedgehog Signalling Pathway (HSP) components, as well as the seminoma TCAM-2 cell line.

Funder

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00606J

Reference63 articles.

1. 1 Developmental roles and clinical significance of Hedgehog signaling

2. Hedgehog signaling in animal development: paradigms and principles

3. Basal cell carcinomas: attack of the hedgehog

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