Catalytic mechanism of the colistin resistance protein MCR-1-Reference-Cited by-同舟云学术

Catalytic mechanism of the colistin resistance protein MCR-1

Published:2021 Issue:17 Volume:19 Page:3813-3819
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Suardíaz Reynier¹²³⁴⁵^ORCID,Lythell Emily¹²³⁴⁵^ORCID,Hinchliffe Philip⁶³⁷⁸⁵^ORCID,van der Kamp Marc¹²³⁴⁵^ORCID,Spencer James⁶³⁷⁸⁵^ORCID,Fey Natalie¹²³⁴⁵^ORCID,Mulholland Adrian J.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Computational Chemistry

2. School of Chemistry

3. University of Bristol

4. Bristol BS8 1TS

5. UK

6. School of Cellular and Molecular Medicine

7. University Walk

8. Bristol BS8 1TD

Abstract

Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.

Funder

Biotechnology and Biological Sciences Research Council

Medical Research Council

Engineering and Physical Sciences Research Council

Royal Society of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02566F

Reference38 articles.