Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment-Reference-Cited by-同舟云学术

Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment

Published:2021 Issue:22 Volume:9 Page:7603-7616
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yu Wei¹,Hu Bin¹,Boakye-Yiadom Kofi Oti¹,Ho William²,Chen Qijing¹,Xu Xiaoyang²,Zhang Xue-Qing¹^ORCID

Affiliation:

1. Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China

2. Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA

Abstract

The intra-articular injection of the ECM-mimicking hydrogel loaded with gene-engineered ADSCs that overexpress TGF-β1 shows a synergistic effect on improving the therapeutic outcomes of OA.

Funder

American Heart Association

National Science Foundation

Shanghai Jiao Tong University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM01122G

Reference55 articles.

1. Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis