Metformin loaded porous particles with bio-microenvironment responsiveness for promoting tumor immunotherapy-Reference-Cited by-同舟云学术

Metformin loaded porous particles with bio-microenvironment responsiveness for promoting tumor immunotherapy

Published:2021 Issue:6 Volume:9 Page:2082-2089
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wen Yuanyuan¹²³⁴⁵^ORCID,Liu Yuxiao⁶⁷⁸⁹⁴^ORCID,Chen Canwen¹⁰¹¹¹²¹³⁴^ORCID,Chi Junjie¹²³⁴⁶^ORCID,Zhong Liping⁵¹⁴¹⁵¹⁶¹⁷,Zhao Yongxiang⁵¹⁴¹⁵¹⁶¹⁷,Zhao Yuanjin¹²³⁴⁶^ORCID

Affiliation:

1. Translational Medicine Laboratory

2. The First Affiliated Hospital of Wenzhou Medical University

3. Wenzhou 325035

4. China

5. National Center for International Biotargeting Theranostics

6. State Key Laboratory of Bioelectronics

7. School of Biological Science and Medical Engineering

8. Southeast University

9. Nanjing

10. Department of Rheumatology and Immunology

11. Institute of Translational Medicine

12. The Affiliated Drum Tower Hospital of Nanjing University Medical School

13. 210008 Nanjing

14. Guangxi Key Laboratory of Biotargeting Theranostics

15. Collaborative Innovation Center for Targeting Tumor Theranostics

16. Guangxi Medical University

17. Guangxi

Abstract

This article presented a novel tumor-microenvironment-responsive particles delivery system with metformin-loaded chitosan inverse opal core and manganese dioxide shell for inhibiting PD-1/PD-L1 signaling pathway and promoting tumor immunotherapy.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01931C

Reference37 articles.

1. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy