Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines-Reference-Cited by-同舟云学术

Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines

Published:2018 Issue:30 Volume:8 Page:16527-16536
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tazaki Taiyu¹²³⁴,Tabata Koshiro⁵⁶⁷⁴,Ainai Akira⁵⁶⁷⁴,Ohara Yuki⁵⁶⁷⁴,Kobayashi Shintaro⁸²⁹⁴,Ninomiya Takafumi¹⁰¹¹¹²⁴,Orba Yasuko⁸²⁹⁴,Mitomo Hideyuki¹³²¹⁴⁴¹⁵^ORCID,Nakano Tetsuo¹⁶¹⁷¹⁸¹⁹²^ORCID,Hasegawa Hideki⁵⁶⁷⁴,Ijiro Kuniharu¹³²¹⁴⁴¹⁵,Sawa Hirofumi⁸²⁹⁴²⁰^ORCID,Suzuki Tadaki⁵⁶⁷⁴,Niikura Kenichi²¹²²²³⁴^ORCID

Affiliation:

1. Graduate School of Chemical Sciences and Engineering

2. Hokkaido University

3. Sapporo 060-8628

4. Japan

5. Department of Pathology

6. National Institute of Infectious Diseases

7. Tokyo 162-8640

8. Research Center for Zoonosis Control

9. Sapporo 001-0020

10. School of Medicine

11. Sapporo Medical University

12. Sapporo 060-8556

13. Research Institute for Electronic Science

14. Sapporo 001-0021

15. Global Station for Soft Matter

16. Technical Research Laboratories

17. Kyowa Hakko Bio Co., Ltd.

18. Hofu 747-8522,Japan

19. Graduate School of Agriculture

20. Global Station for Zoonosis Control

21. Department of Innovative Systems Engineering

22. Nippon Institute of Technology

23. Saitama 345-8501

Abstract

Conjugation with gold nanorods enhanced the adjuvanticity of RNA adjuvant for intranasal inactivated influenza vaccines, providing efficient protection against infection in mice.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA01690A

Reference59 articles.

1. Past Efforts and Future Prospects for a Nasal Influenza Vaccine