A spot test for determination of residual TBA levels in18F-radiotracers for human use using Dragendorff reagent-Reference-Cited by-同舟云学术

A spot test for determination of residual TBA levels in18F-radiotracers for human use using Dragendorff reagent

Published:2020 Issue:41 Volume:12 Page:5004-5009
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Tanzey Sean S.¹²³⁴⁵^ORCID,Mossine Andrew V.¹²³⁴,Sowa Alexandra R.¹²³⁴^ORCID,Torres Jovany¹²³⁴,Brooks Allen F.¹²³⁴^ORCID,Sanford Melanie S.⁶²³⁴^ORCID,Scott Peter J. H.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Radiology

2. University of Michigan

3. Ann Arbor

4. USA

5. Department of Medicinal Chemistry

6. Department of Chemistry

Abstract

A TLC spot test for determining residual TBA levels in positron emission tomography (PET) radiotracer formulations has been developed using Dragendorff reagent. Proof-of-concept is demonstrated by quantification of residual TBA in 6-[¹⁸F]fluoro-DOPA.

Funder

University of Michigan

National Institute of Biomedical Imaging and Bioengineering

Office of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/D0AY01565B

Reference33 articles.

1. Molecular Imaging with PET