The thermodynamics of endosomal escape and DNA release from lipoplexes

Author:

Avital Yotam Y.12345,Grønbech-Jensen Niels678910,Farago Oded12345

Affiliation:

1. Department of Biomedical Engineering

2. Ben-Gurion University of the Negev

3. Be'er Sheva 85105

4. Israel

5. Ilae Katz Institute for Nanoscale Science and Technology

6. Department of Mechanical and Aerospace Engineering

7. University of California

8. Davis

9. USA

10. Department Mathematics

Abstract

In this work we identify and characterize the entropic driving forces governing the process of transfection by lipid–DNA complexes.

Funder

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference23 articles.

1. Gene Therapy. Therapeutic mechanisms and strategies, ed. N. Smyth-Templeton and D. D. Lasic, Marcel Dekker Inc., New York, 2000

2. Artificial Self-Assembling Systems for Gene Delivery, ed. P. L. Felgner, M. J. Heller, P. Lehn, J.-P. Behr and F. C. Szoka, American Chemical Society, Washington, DC, 1996

3. Cationic Liposomes for Gene Therapy

4. Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics, ed. R. I. Mahato and S. W. Kim, Taylor and Francis, London and New York, 2002

5. Non-Viral Vectors for Gene Therapy, ed. L. Huang, M.-C. Hung and E. Wagner, Elsevier, San Diego, 2005

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