Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice

Author:

Shi Jialu12345ORCID,Du Peng12345,Xie Qinggang6785,Wang Nana12345,Li Huizhen12345,Smith Etareri Evivie12345,Li Chun12345,Liu Fei12345,Huo Guicheng12345ORCID,Li Bailiang12345ORCID

Affiliation:

1. Key Laboratory of Dairy Science

2. Ministry of Education

3. Northeast Agricultural University

4. Harbin 150030

5. China

6. Heilongjiang Feihe Dairy Co.

7. Ltd

8. Qiqihaer 164800

Abstract

L. plantarum KLDS 1.0386 combined with tryptophan alleviates ulcerative colitis (UC) induced by dextran sodium sulfate (DSS) by increasing the level of indole-3-acetic acid (IAA), stimulating the AHR/IL-22/STAT3 signaling pathway and regulating gut microbiota in mice.

Funder

Natural Science Foundation of Heilongjiang Province

National Key Research and Development Program of China

National Natural Science Foundation of China

Northeast Agricultural University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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