Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases-Reference-Cited by-同舟云学术

Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases

Published:2023 Issue:9 Volume:40 Page:1550-1582
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Patel Ketan D.¹^ORCID,MacDonald Monica R.¹^ORCID,Ahmed Syed Fardin¹^ORCID,Singh Jitendra¹^ORCID,Gulick Andrew M.¹^ORCID

Affiliation:

1. University at Buffalo, Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, 55 Main St. Buffalo, NY 14203, USA

Abstract

Nonribosomal peptide synthetases use a modular architecture to catalyze production of peptide natural products. Structural studies provide insights into the multidomain organization as well as the structural basis of catalytic domain activity.

Funder

National Institute of General Medical Sciences

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NP/D3NP00003F

Reference250 articles.

1. A chemocentric view of the natural product inventory

2. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

3. New developments in RiPP discovery, enzymology and engineering

4. Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature

5. Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains

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