Iterative addition of carbon nucleophiles to N,N-dialkyl carboxamides for synthesis of α-tertiary amines-Reference-Cited by-同舟云学术

Iterative addition of carbon nucleophiles to N,N-dialkyl carboxamides for synthesis of α-tertiary amines

Published:2022 Issue:1 Volume:13 Page:99-104
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Jiahua¹,Lim Jun Wei¹,Ong Derek Yiren¹,Chiba Shunsuke¹^ORCID

Affiliation:

1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Abstract

We herein report a concise protocol for iterative addition of carbon nucleophiles to N,N-dialkyl carboxamides for the synthesis of α-tertiary amines.

Funder

Ministry of Education – Singapore

Nanyang Technological University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC05876B

Reference67 articles.

1. Synthetic approaches towards alkaloids bearing α-tertiary amines

2. The importance of synthetic chemistry in the pharmaceutical industry

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5. Intermolecular radical carboamination of alkenes

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