Asymmetric 1,3-dipolar cycloaddition of 4-amino pyrazolone-based azomethine ylides: a straightforward approach to spiropyrazolones-Reference-Cited by-同舟云学术

Asymmetric 1,3-dipolar cycloaddition of 4-amino pyrazolone-based azomethine ylides: a straightforward approach to spiropyrazolones

Published:2022 Issue:13 Volume:9 Page:3585-3590
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Huang Yue¹,Wei Xingfu¹,Bao Xiaoze¹,Nawaz Shah¹^ORCID,Qu Jingping¹^ORCID,Wang Baomin¹^ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China

Abstract

An asymmetric [3 + 2] cycloaddition of 4-amino pyrazolone-derived azomethine ylides with α,β-enones has been established for the synthesis of 4-spiropyrazolone derivatives with four contiguous stereocenters.

Funder

Central University Basic Research Fund of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00426G

Reference61 articles.

1. Chiral Diphosphine and Monodentate Phosphorus Ligands on a Spiro Scaffold for Transition-Metal-Catalyzed Asymmetric Reactions

2. Spiro Skeletons: A Class of Privileged Structure for Chiral Ligand Design

3. Organo-Cation Catalyzed Asymmetric Homo/Heterodialkylation of Bisoxindoles: Construction of Vicinal All-Carbon Quaternary Stereocenters and Total Synthesis of (−)-Chimonanthidine

4. Atroposelective Synthesis of Axially Chiral 3-Arylindoles by Copper-Catalyzed Asymmetric Cross-Coupling of Indoles with Quinones and Naphthoquinones

5. Advances in Spirocyclic Hybrids: Chemistry and Medicinal Actions

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