Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction-Reference-Cited by-同舟云学术

Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction

Published:2020 Issue:28 Volume:18 Page:5359-5369
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Strizhak Alexander V.¹²³⁴⁵,Babii Oleg⁶⁷⁸⁹^ORCID,Afonin Sergii⁶⁷⁸⁹^ORCID,Bakanovich Iuliia¹²³⁴⁵,Pantelejevs Teodors¹⁰²¹¹⁴,Xu Wenshu¹²³⁴,Fowler Elaine¹²³⁴^ORCID,Eapen Rohan¹²²¹³⁴^ORCID,Sharma Krishna¹²³⁴^ORCID,Platonov Maxim O.⁵¹⁴¹⁵^ORCID,Hurmach Vasyl V.⁵¹⁴¹⁵¹⁶¹⁷,Itzhaki Laura¹²²¹³⁴,Hyvönen Marko¹⁰²¹¹⁴^ORCID,Ulrich Anne S.⁶⁷⁸⁹¹⁸^ORCID,Spring David R.¹²³⁴^ORCID,Komarov Igor V.¹⁶¹⁷¹⁵¹⁹²⁰^ORCID

Affiliation:

1. University Chemical Laboratory

2. University of Cambridge

3. CB2 1EW Cambridge

4. UK

5. Enamine Ltd

6. Institute of Biological Interfaces (IBG-2)

7. Karlsruhe Institute of Technology (KIT)

8. 76021 Karlsruhe

9. Germany

10. Department of Biochemistry

11. CB2 1GA Cambridge

12. Department of Pharmacology

13. CB2 1PD Cambridge

14. 02094 Kyiv

15. Ukraine

16. Taras Shevchenko National University of Kyiv

17. 01601 Kyiv

18. Institute of Organic Chemistry (IOC)

19. Lumobiotics GmbH

20. Karlsruhe

Abstract

Photoisomerization of diarylethene-modified peptides changes the thermodynamics of their binding to MDM2: the “closed” photoisomers bind largely due to a high negative enthalpy, whereas the “open” forms bind better due to a more favourable entropy.

Funder

Medical Research Council

Deutsche Forschungsgemeinschaft

H2020 Marie Skłodowska-Curie Actions

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00831A

Reference93 articles.