Elucidation of the atroposelectivity in the synthesis of axially chiral thiohydantoin derivatives
Author:
Affiliation:
1. Department of Chemistry
2. Bogaziçi University
3. Istanbul
4. Turkey
5. Université de Lorraine
6. Faculty of Pharmacy
7. Acibadem Mehmet Ali Aydinlar University
8. CNRS
9. LPCT
10. F-54000 Nancy
11. France
Abstract
A DFT study is carried out in order to elucidate the racemization and cyclization mechanism as well as the atroposelectivity during the synthesis of 2-thiohydantoins. Computational data shows that the racemization occurs after cyclization with the assistance of triethyl amine.
Funder
Boğaziçi Üniversitesi
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02556A
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5. Peripheral inhibition of thyroxine by thiohydantoins derived from amino acids
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