Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood–brain barrier via carbon nitride dots
Author:
Affiliation:
1. Department of Chemistry
2. University of Miami
3. Coral Gables
4. USA
5. King Abdulaziz University
6. Jeddah 21589
7. Kingdom of Saudi Arabia
8. Department of Neurological Surgery
9. Miller School of Medicine
10. Miami
Abstract
A carbon nitride dot nanocarrier system with effective drug conjugation and selective target delivering to achieve enhanced drug efficacy on pediatric glioblastomas, while proving capability to penetrate blood–brain barrier.
Funder
National Science Foundation
King Abdulaziz University
University of Miami
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science
Link
http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR01647K
Reference47 articles.
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2. N.C. Institute , Adult central nervous system tumors treatment (PDQ®)–patient version , 2018
3. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015
4. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers
5. Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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