Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation-Reference-Cited by-同舟云学术

Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation

Published:2022 Issue:20 Volume:13 Page:10401-10414
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chang Anna¹²,Chang Yi¹³,Wang Su-Jane¹⁴^ORCID

Affiliation:

1. School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan

2. Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 22060, Taiwan

3. Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 22060, Taiwan

4. Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan

Abstract

Pretreatment of rats with rutin attenuated KA-induced seizures and neuronal loss by decreasing glutamatergic hyperactivity and IL-1R1/TLR4-related neuroinflammatory casade. Our findings provide clues to understand the mechanism of rutin in epilepsy intervention.

Funder

Ministry of Science and Technology

Shin Kong Wu Ho-Su Memorial Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01490D

Reference74 articles.

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2. Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain