Synthesis and P-glycoprotein induction activity of colupulone analogs-Reference-Cited by-同舟云学术

Synthesis and P-glycoprotein induction activity of colupulone analogs

Published:2015 Issue:19 Volume:13 Page:5488-5496
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bharate Jaideep B.¹²³⁴⁵,Batarseh Yazan S.⁶⁷⁸,Wani Abubakar⁹¹⁰³⁴,Sharma Sadhana⁵¹⁰³⁴⁹,Vishwakarma Ram A.¹²³⁴⁵,Kaddoumi Amal⁶⁷⁸,Kumar Ajay⁹¹⁰³⁴,Bharate Sandip B.¹²³⁴⁵

Affiliation:

1. Medicinal Chemistry Division

2. CSIR-Indian Institute of Integrative Medicine (CSIR)

3. Jammu-180001

4. India

5. Academy of Scientific & Innovative Research (AcSIR)

6. School of Pharmacy

7. The University of Louisiana at Monroe

8. USA

9. Cancer Pharmacology Division

10. CSIR-Indian Institute of Integrative Medicine

Abstract

A diprenylated acylphloroglucinol was identified as a potent P-gp inducer and showing ability to increase amyloid-beta transport across BBB, thus it is a potential anti-Alzheimer lead compound.

Funder

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00554J

Reference28 articles.

1. Phloroglucinol compounds of natural origin

2. Polycyclic Polyprenylated Acylphloroglucinols

3. Bioactive acylphloroglucinol derivatives from Eucalyptus species