Stability and structure–activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury-Reference-Cited by-同舟云学术

Stability and structure–activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury

Published:2023 Issue:27 Volume:13 Page:18864-18877
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Chowdhury Asif Alam¹^ORCID,Rodgers Karla²^ORCID,Godbole Nachiket M.¹^ORCID,Awasthi Shanjana¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Oklahoma City, OK-73117, USA

2. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd, Oklahoma City, OK-73104, USA

Abstract

Presented work in this article describes the structure of SPA4 peptide in ambient conditions, simulated lung fluids and chemical components, and structure–activity relation of SPA4 peptide against lipopolysaccharide stimuli.

Funder

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02918B

Reference58 articles.

1. Endotoxin recognition and signal transduction by the TLR4/MD2-complex

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3. TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection

4. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation

5. Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury