Design, synthesis, <i>in silico</i>, and <i>in vitro</i> evaluation of benzylbenzimidazolone derivatives as potential drugs on α-glucosidase and glucokinase as pharmacological targets-Reference-Cited by-同舟云学术

Design, synthesis, in silico, and in vitro evaluation of benzylbenzimidazolone derivatives as potential drugs on α-glucosidase and glucokinase as pharmacological targets

Published:2023 Issue:31 Volume:13 Page:21153-21162
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Santos-Ballardo Cress Lumadhar¹^ORCID,Montes-Ávila Julio¹^ORCID,Rendon-Maldonado José Guadalupe¹^ORCID,Ramos-Payan Rosalio¹^ORCID,Montaño Sarita¹^ORCID,Sarmiento-Sánchez Juan I.²,Acosta-Cota Selene de Jesús³^ORCID,Ochoa-Terán Adrián⁴^ORCID,Bastidas-Bastidas Pedro de Jesús⁵^ORCID,Osuna-Martínez Ulises¹^ORCID

Affiliation:

1. Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, México

2. Facultad de Ingeniería Civil, Universidad Autónoma de Sinaloa, México

3. Departamento de Ciencias de la Salud, Universidad Autónoma de Occidente, México

4. Centro de Graduados e Investigación en Química, Instituto Tecnológico de Tijuana, México

5. Laboratorio de Análisis de Residuos de Plaguicidas, Centro de Investigación en Alimentación y Desarrollo A.C., México

Abstract

An in silico assay was designed, and generated compounds were studied to delimitate the synthesis by microwave irradiation–conventional heat combination. In vitro evaluation as antihyperglycemic and hypoglycemic agents were made, where 2s has good potential.

Funder

Universidad Autónoma de Sinaloa

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02916F

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1. Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties

2. Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

3. Copper-catalyzed efficient synthesis of a 2-benzimidazolone scaffold from 2-nitroaniline and dimethyl carbonate via a hydrosilylation reaction

4. Synthesis, α-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives

5. Conjugates of Degraded and Oxidized Hydroxyethyl Starch and Sulfonylureas: Synthesis, Characterization, and in Vivo Antidiabetic Activity

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