Functionalization of 3D printed polymeric bioresorbable stents with a dual cell-adhesive peptidic platform combining RGDS and YIGSR sequences

Author:

Chausse Victor123ORCID,Mas-Moruno Carlos123ORCID,Martin-Gómez Helena123,Pino Marc4,Díaz-Ricart Maribel4,Escolar Ginés4,Ginebra Maria-Pau125ORCID,Pegueroles Marta123

Affiliation:

1. Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), EEBE, Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain

2. Barcelona Research Center in Multiscale Science and Engineering, UPC, Eduard Maristany, 10-14, 08019 Barcelona, Spain

3. Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain

4. Hematopathology, Pathology Department, Centre de Diagnòstic Biomèdic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Spain

5. Institute for Bioengineering of Catalonia (IBEC), 08028 Barcelona, Spain

Abstract

The functionalization of 3D-printed poly-l-lactic acid (PLLA) and poly(l-lactic-co-ε-caprolactone) (PLCL) bioresorbable stents has been successfully achieved with linear RGDS and YIGSR peptides, as well as a dual platform containing both motifs within a single biomolecule.

Funder

Agència de Gestió d'Ajuts Universitaris i de Recerca

Ministerio de Ciencia e Innovación

European Regional Development Fund

Generalitat de Catalunya

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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