Surface modification: activation and deactivation of osteogenic differentiation based on detachable growth factor protein

Author:

Guan Zhen-Yu1234,Chen Yi-Kai5234,Wu Chih-Yu1234,Wu Shinn-Chih5234,Yu Jiashing1234ORCID,Chen Hsien-Yeh1234ORCID

Affiliation:

1. Department of Chemical Engineering

2. National Taiwan University

3. Taipei 10617

4. Taiwan

5. Department of Animal Science and Technology

Abstract

An advanced interface is modified by using a detachable poly-para-xylylene coating to immobilize BMP-2 with a mechanism to subsequently detach the BMP-2 at a programmable time point of interest, and the associated osteogenesis is controlled via an activated or deactivated activity.

Funder

Ministry of Science and Technology, Taiwan

National Taiwan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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