Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides-Reference-Cited by-同舟云学术

Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

Published:2018 Issue:43 Volume:16 Page:8025-8029
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hong Xiao-Qiao¹²³⁴⁵,Yu Xi-Hui¹²³⁴⁵,Zhang Kun⁶⁷⁸⁵⁹,Chen Wen-Hua¹²³⁴⁵^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening

2. School of Pharmaceutical Sciences

3. Southern Medical University

4. Guangzhou 510515

5. P. R. China

6. School of Biotechnology and Health Sciences

7. Wuyi University

8. Jiangmen 529020

9. International Healthcare Innovation Institute (Jiangmen)

Abstract

A squaramide derivative bearing a coumarin fluorophore and a morpholinyl group was synthesized and found to be able to target and efficiently deacidify lysosomes.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01957F

Reference23 articles.

1. Anion transport and supramolecular medicinal chemistry

2. Small-Molecule Lipid-Bilayer Anion Transporters for Biological Applications

3. Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

4. Chloride Transport through Supramolecular Barrel-Rosette Ion Channels: Lipophilic Control and Apoptosis-Inducing Activity

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