Development of a low level detection method for 2-chloromalonaldehyde in active pharmaceutical ingredients by HILIC separation-Reference-Cited by-同舟云学术

Development of a low level detection method for 2-chloromalonaldehyde in active pharmaceutical ingredients by HILIC separation

Published:2016 Issue:23 Volume:8 Page:4659-4663
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Denton Justin R.¹²³,Berwick Lorrie¹²³,Loughlin Thomas P.¹²³

Affiliation:

1. MMD Analytical Development and Commercialization – Active Pharmaceutical Ingredient

2. Rahway

3. USA

Abstract

2-Chloromalonaldehyde (2-ClMA) is utilized in the pharmaceutical sector as a reagent to form thiazole heterocycles which can be further functionalized. In silico assessment has flagged 2-ClMA as a potential mutagenic impurity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/AY/C6AY01257D

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