Accumulation of camptothecin and 10-hydroxycamptothecin and the transcriptional expression of camptothecin biosynthetic genes in Camptotheca acuminata cambial meristematic and dedifferentiated cells-Reference-Cited by-同舟云学术

Accumulation of camptothecin and 10-hydroxycamptothecin and the transcriptional expression of camptothecin biosynthetic genes in Camptotheca acuminata cambial meristematic and dedifferentiated cells

Published:2017 Issue:20 Volume:7 Page:12185-12193
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Yuhua¹²³⁴⁵,Jiang Keming¹²³⁴,Qing Degang⁶⁷⁴,Huang Bing¹²³⁴,Jiang Jiayi¹²³⁴,Wang Shumei⁵⁸⁹⁴,Yan Chunyan¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy

2. Guangdong Pharmaceutical University

3. Guangzhou 510006

4. China

5. Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM

6. XinJiang Institute of Chinese Materia Medica and Ethnodrug

7. Urumqi 830002

8. P. R. China

9. Engineering & Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province

Abstract

Cambial meristematic cells (CMCs) of C. acuminata were isolated and compared with dedifferentiated cells (DDCs). The expression levels of seven genes encoding key enzymes involved in CPT and HCPT biosynthesis was significantly upregulated in CMCs compared with DDCs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA00588A

Reference34 articles.

1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

2. Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots

3. Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature

4. Sites of Accumulation of the Antitumor Alkaloid Camptothecin inCamptotheca acuminata

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