Organocatalytic asymmetric Friedel–Crafts alkylation/hemiketalization/lactonization cascade reactions: highly enantioselective synthesis of furo[2,3-b]benzofuranones-Reference-Cited by-同舟云学术

Organocatalytic asymmetric Friedel–Crafts alkylation/hemiketalization/lactonization cascade reactions: highly enantioselective synthesis of furo[2,3-b]benzofuranones

Published:2020 Issue:13 Volume:7 Page:1679-1684
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Kunhua¹²³⁴⁵,Chen Wenming⁶⁷⁸⁵,Chen Xu¹²³⁴⁵,Wang Biao¹²³⁴⁵,Huang Jun⁹¹⁰¹¹³⁴,Tian Xu¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease

2. School of Pharmaceutical Sciences & The Fifth Affiliated Hospital

3. Guangzhou Medical University

4. Guangzhou

5. China

6. Department of Pharmaceutical Production Center

7. The First Affiliated Hospital of Hunan University of Chinese Medicine

8. Changsha

9. Sino-French Hoffmann Institute

10. Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology

11. The Second Affiliated Hospital

Abstract

A highly diastereo- and enantioselective organocatalytic Friedel–Crafts alkylation/hemiketalization/lactonization cascade reaction generating furo[2,3-b]benzofuranones in good to excellent yields with high stereoselectivities.

Funder

National Natural Science Foundation of China

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00475H

Reference59 articles.

1. The art of total synthesis through cascade reactions

2. Catalytic Cascade Reactions , ed. P.-F. Xu and W. Wang , Wiley-VCH , Weinheim , 2013