A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma-Reference-Cited by-同舟云学术

A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma

Published:2022 Issue:23 Volume:10 Page:6791-6803
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Xie Yandong¹^ORCID,Lu Xueying²,Wang Zhen¹,Liu Mingxi¹,Liu Liang¹,Wang Ran¹,Yang Kun¹,Xiao Hong³,Li Jianyong²,Tang Xianglong¹³,Liu Hongyi¹

Affiliation:

1. Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China

2. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing Medical University, Nanjing 210029, China

3. Department of Neuro-Psychiatric Institute, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing 210029, China

Abstract

Due to the unique chemical properties of metronidazoles under hypoxic conditions, RDPP(Met) liposomes were found to promote the release of TMZ and siMGMT in hypoxic cells and have strong radiosensitivity for GBM.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM01145J

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