Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties

Author:

Lan Chenyang123,Stulz Anja4,Barthes Nicolas P. F.4ORCID,Lauw Susan56,Salavei Pavel56,Jung Manfred34ORCID,Heerklotz Heiko3457,Ulbrich Maximilian H.58ORCID

Affiliation:

1. Faculty of Biology, University of Freiburg, Germany

2. Institute of Physical Chemistry, University of Freiburg, Germany

3. CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Germany

4. Institute of Pharmaceutical Sciences, University of Freiburg, Germany

5. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Germany

6. Core Facility Signalling Factory & Robotics, University of Freiburg, Germany

7. Leslie Dan Faculty of Pharmacy, University of Toronto, Germany

8. Internal Medicine IV, University of Freiburg Medical Center and Faculty of Medicine, University of Freiburg, Germany

Abstract

A pair of designed transmembrane proteins form a dimer at the cell surface, as seen by single molecule imaging. Changes in the linker length or binding domain modulate the 2-dimensional binding affinity.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3