Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system-Reference-Cited by-同舟云学术

Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system

Published:2016 Issue:1 Volume:5 Page:278-290
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Richter M.¹²³⁴,Fairhall E. A.⁵⁶⁷⁸,Hoffmann S. A.¹²³⁴,Tröbs S.¹²³⁴,Knöspel F.¹²³⁴,Probert P. M. E.⁵⁶⁷⁸,Oakley F.⁵⁶⁷⁸,Stroux A.⁹²³⁴,Wright M. C.⁵⁶⁷⁸,Zeilinger K.¹²³⁴

Affiliation:

1. Berlin-Brandenburg Center for Regenerative Therapies (BCRT)

2. Charité-Universitätsmedizin Berlin

3. Berlin

4. Germany

5. Newcastle University

6. Institute Cellular Medicine

7. Newcastle Upon Tyne

8. UK

9. Institute for Biometry and Clinical Epidemiology

Abstract

The rat pancreatic progenitor cell line B-13 is of interest for research on drug metabolism and toxicity since the cells trans-differentiate into functional hepatocyte-like cells (B-13/H) when treated with glucocorticoids.

Funder

Alternatives Research and Development Foundation

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00187K

Reference30 articles.

1. AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes

2. Molecular basis of transdifferentiation of pancreas to liver

3. Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro

4. Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid

5. The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells

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