Single-pot enzymatic synthesis of cancer-associated MUC16 O-glycopeptide libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines-Reference-Cited by-同舟云学术

Single-pot enzymatic synthesis of cancer-associated MUC16 O-glycopeptide libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines

Published:2021 Issue:20 Volume:45 Page:9197-9211
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Freitas Rui¹²³⁴⁵,Relvas-Santos Marta¹²³⁴⁵^ORCID,Azevedo Rita¹²³⁴,Soares Janine¹²³⁴⁵,Fernandes Elisabete¹²³⁴⁶,Teixeira Beatriz¹²³⁴⁵,Santos Lúcio Lara¹²³⁴⁷,Silva André M. N.⁷⁸⁹¹⁰¹¹^ORCID,Ferreira José Alexandre¹²³⁴⁵^ORCID

Affiliation:

1. Experimental Pathology and Therapeutics Group

2. Portuguese Oncology Institute of Porto

3. 4200-072 Porto

4. Portugal

5. Institute of Biomedical Sciences Abel Salazar (ICBAS)

6. Institute for Research and Innovation in Health (i3S)

7. REQUIMTE-LAQV

8. Department of Chemistry and Biochemistry

9. Faculty of Sciences

10. University of Porto

11. 4169-007 Porto

Abstract

Glycosyltransferases and nucleotide sugars are combined in single-pot settings to synthesize a library of cancer-associated MUC16 O-glycopeptides and multivalent protein glycoconjugates foreseeing future development of cancer glycovaccines.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D0NJ06021F

Reference44 articles.

1. Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine

2. Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

3. Applications of synthetic carbohydrates to chemical biology

4. Glycosyltransferases as biocatalysts

5. P. H. Seeberger , N.Finney , D.Rabuka and C. R.Bertozzi , in Essentials of Glycobiology , ed. A. Varki , R. D. Cummings , J. D. Esko , H. H. Freeze , P. Stanley , C. R. Bertozzi , G. W. Hart and M. E. Etzler , Cold Spring Harbor , NY , 2009

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