Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae

Published:2018 Issue:1 Volume:9 Page:105-118
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Glauninger Hendrik¹²³⁴,Zhang Yifan¹²³⁴⁵,Higgins Khadine A.¹²³⁴¹,Jacobs Alexander D.¹²³⁴,Martin Julia E.¹²³⁴,Fu Yue¹²³⁴⁵,Coyne, 3rd H. Jerome¹²³⁴,Bruce Kevin E.⁶²³⁴,Maroney Michael J.¹⁷⁴,Clemmer David E.¹²³⁴,Capdevila Daiana A.¹²³⁴,Giedroc David P.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Indiana University

3. Bloomington

4. USA

5. Department of Molecular and Cellular Biochemistry

6. Department of Biology

7. University of Massachusetts

Abstract

The dynamics and marginal stability of CopY enable allosteric activation of DNA binding by Zn(ii) and inhibition by Cu(i).

Funder

National Institute of General Medical Sciences