<i>Petasites japonicus</i> leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation-Reference-Cited by-同舟云学术

Petasites japonicus leaf extract inhibits Alzheimer's-like pathology through suppression of neuroinflammation

Published:2022 Issue:20 Volume:13 Page:10811-10822
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Eo Hyeyoon¹^ORCID,Lee Seungmin¹,Kim Seong Hye¹,Ju In Gyoung²,Huh Eugene²,Lim Jeongin³,Park Sangsu³,Oh Myung Sook¹²⁴^ORCID

Affiliation:

1. Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

2. Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea

3. NATUREBIO Co., Ltd., Seoul Biohub Industry-Academic Cooperation Center, Seoul 02447, Republic of Korea

4. Department of Integrated Drug Development and Natural Products, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

Abstract

Neuroinflammation is a crucial step involved in development and progression of Alzheimer's disease. The current study found that Petasites japonicus leaf extract inhibits neuroinflammation induced by lipopolysaccharides and amyloid beta oligomers.

Funder

Ministry of SMEs and Startups

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO01989B

Reference55 articles.

1. When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Disease

2. Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease

3. Amyloid beta: structure, biology and structure-based therapeutic development