Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides-Reference-Cited by-同舟云学术

Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides

Published:2022 Issue:5 Volume:13 Page:1398-1407
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Xu Xiao¹,Bao Longzhu¹,Ran Lu¹,Yang Zhenyan¹,Yan Dingce²,Wang Chun-Jiang³^ORCID,Teng Huailong¹^ORCID

Affiliation:

1. College of Science, Huazhong Agricultural University, Wuhan, 430070, P. R. China

2. Analytical and Testing Center, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China

3. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China

Abstract

Chiral fluoropyrrolidines were synthesized by Cu(i)-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides with less active fluorinated styrenes, with broad substrate scope and high yield, stereoselectivity and biological activity.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC04595D

Reference72 articles.

1. The fluorinated natural products

2. T.Hiyama , Organofluorine compounds: chemistry and applications , 2000 , Springer Science & Business Media