Effective SARS-CoV-2 antiviral activity of hyperbranched polylysine nanopolymers

Author:

Stagi Luigi1ORCID,De Forni Davide2,Malfatti Luca1ORCID,Caboi Francesca3,Salis Andrea4ORCID,Poddesu Barbara2,Cugia Giulia2,Lori Franco2,Galleri Grazia5,Innocenzi Plinio1ORCID

Affiliation:

1. Laboratorio di Scienza dei Materiali e Nanotecnologie (LMNT), Dipartimento di Chimica e Farmacia, CR-INSTM, Università di Sassari, Via Vienna 2, 07041 Sassari, Italy

2. ViroStatics srl, Viale Umberto I, 46, 07100 Sassari, Italy

3. Laboratorio NMR e Tecnologie Bioanalitiche, Sardegna Ricerche, Parco Scientifico e Tecnologico della Sardegna, 09010 Pula, CA, Italy

4. Dipartimento di Scienze Chimiche e Geologiche, Università di Cagliari, Cittadella Universitaria, SS 554 bivio Sestu, 09042 Monserrato, CA, Italy

5. Dipartimento di Science Mediche, Chirurgiche e Sperimentali, Viale S. Pietro 8, 07100 Sassari, Italy

Abstract

Hyperbranched polylysine nanopolymers effectively inhibit the viral activity of SARS-CoV-2.

Funder

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference62 articles.

1. Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

2. Centers for Disease Control and Prevention. Science Brief: Emerging SARS-CoV-2 Variants [Cited 2021 January 28]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/scientific-brief-emerging-variants.html

3. Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

4. P. C.Resende , J. F.Bezerra , R. H. T.de Vasconcelos , I.Arantes , L.Appolinario , A. C.Mendonca , et al. , Spike E484K mutation in the first SARS-CoV-2 reinfection case confirmed in Brazil, 2020 [Posted 2021 January 10]. Available from: https://virological.org/t/spike-e484k-mutation-in-the-first-sars-cov-2-reinfection-case-confirmed-in-brazil-2020/584

5. Materials science approaches in the development of broad-spectrum antiviral therapies

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