Organic dye-photocatalyzed fluoroalkylation of heteroarene-N-oxide derivatives-Reference-Cited by-同舟云学术

Organic dye-photocatalyzed fluoroalkylation of heteroarene-N-oxide derivatives

Published:2018 Issue:36 Volume:16 Page:6718-6727
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lantaño Beatriz¹²³⁴^ORCID,Barata-Vallejo Sebastián¹²³⁴^ORCID,Postigo Al¹²³⁴^ORCID

Affiliation:

1. Departamento de Quimica Organica

2. Universidad de Buenos Aires Facultad de Farmacia y Bioquimica

3. CP 1113-Buenos Aires

4. Argentina

Abstract

A direct C_Het–H perfluoroalkylation reaction of heteroaromatic-N-oxides has been achieved. Acid-catalyzed transformation of the perfluoroalkylated-N-oxides leads to 2-(perfluoroalkyl)benzo[f][1,3]oxazepines. De-oxygenation of the perfluoroalkylated heteroaromatic-N-oxides affords a regioselective radical perfluoroalkylation protocol.

Funder

Universidad de Buenos Aires

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01653D

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1. Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

2. The history of the development of minoxidil