Recent advances in chemical biology tools for protein and RNA profiling of extracellular vesicles

Author:

Lim Woojeong1,Lee Soyeon1,Koh Minseob2ORCID,Jo Ala3,Park Jongmin145ORCID

Affiliation:

1. Department of Chemistry, Kangwon National University, Chuncheon 24341, Korea

2. Department of Chemistry, Pusan National University, Busan 46241, Republic of Korea

3. Center for Nanomedicine, Institute for Basic Science, Seoul 03722, Republic of Korea

4. Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon 24341, Republic of Korea

5. Multidimensional Genomics Research Center, Kangwon National University, Chuncheon 24341, Republic of Korea

Abstract

This review provides an overview of how chemical biology tools have been applied for efficient EV isolation, the increment of EV detection sensitivity, multiplexed analysis of EV protein, metabolic labeling of EVs, and drug occupancy of EV proteins.

Funder

Kangwon National University

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

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