Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer-Reference-Cited by-同舟云学术

Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer

Published:2021 Issue:29 Volume:19 Page:6501-6512
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Almeida José¹²³⁴⁵^ORCID,Zhang Guanyu⁶⁷⁸⁹,Wang Maodie⁶⁷⁸⁹,Queirós Carla¹²³⁴⁵^ORCID,Cerqueira Ana F. R.¹⁶¹⁰¹¹⁵^ORCID,Tomé Augusto C.¹⁶¹⁰¹¹⁵^ORCID,Barone Giampaolo¹²¹³¹⁴¹⁵¹⁶^ORCID,Vicente M. Graça H.⁶⁷⁸⁹^ORCID,Hey-Hawkins Evamarie¹⁷¹⁸¹⁹²⁰²¹^ORCID,Silva Ana M. G.¹²³⁴⁵^ORCID,Rangel Maria¹²²²³²⁴⁵^ORCID

Affiliation:

1. LAQV-REQUIMTE

2. Departamento de Química e Bioquímica

3. Faculdade de Ciências da Universidade do Porto

4. 4169-007 Porto

5. Portugal

6. Department of Chemistry

7. Louisiana State University

8. Baton Rouge

9. USA

10. University of Aveiro

11. 3810-193 Aveiro

12. Dipartimento di Scienze e Tecnologie Biologiche

13. Chimiche e Farmaceutiche

14. Università di Palermo

15. 90128 Palermo

16. Italy

17. Institute of Inorganic Chemistry

18. Faculty of Chemistry and Mineralogy

19. Leipzig University

20. 04103 Leipzig

21. Germany

22. Instituto de Ciências Biomédicas Abel Salazar

23. Universidade do Porto

24. 4099-003 Porto

Abstract

The efficient synthesis of porphyrin– and chlorin–NSAID conjugates, and their singlet oxygen generation capacity and HEp2 cell toxicity are reported.

Funder

Fundação para a Ciência e a Tecnologia

Ministério da Ciência, Tecnologia e Ensino Superior

European Social Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01015H

Reference70 articles.

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2. A Self-Assembled Cofacial Cobalt Porphyrin Prism for Oxygen Reduction Catalysis

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5. New photosensitizers for photodynamic therapy

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