Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer-Reference-Cited by-同舟云学术

Direct discrimination of cell surface glycosylation signatures using a single pH-responsive boronic acid-functionalized polymer

Published:2022 Issue:43 Volume:13 Page:12899-12905
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Jiang Mingdi¹^ORCID,Chattopadhyay Aritra Nath¹,Li Cheng Hsuan¹,Geng Yingying¹,Luther David C.¹^ORCID,Huang Rui¹,Rotello Vincent M.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA

Abstract

A high-content multichannel sensor array was developed to efficiently discriminate cell states. The binding of boronic acid with glycans is pH-responsive, hence utilizing three pH provides a sensitive multidimensional array from a single polymer.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02116A

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