Capturing a novel metastable polymorph of the anticancer drug gefitinib-Reference-Cited by-同舟云学术

Capturing a novel metastable polymorph of the anticancer drug gefitinib

Published:2014 Issue:37 Volume:16 Page:8638-8641
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Thorat Shridhar H.¹²³,Patwadkar Manjusha V.⁴²³,Gonnade Rajesh G.¹²³,Vaidhyanathan R.⁵⁶³

Affiliation:

1. Center for Materials Characterization

2. CSIR-National Chemical Laboratory

3. Pune, India

4. Polymer Science and Engineering Division

5. Department of Chemistry

6. Indian Institute of Science Education and Research

Abstract

The anticancer drug gefitinib exhibited conformational polymorphism, revealing 3D isostructurality in the molecular organization, and slight differences in the stacking pattern. The kinetic (red) polymorph undergoes a crystal-to-crystal thermal phase transition to the thermodynamic (blue) form.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CE/C4CE01446D

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5. Physicochemical characterization of furosemide modifications

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