An environmentally responsible route to tezacaftor, a drug for treatment of cystic fibrosis prepared in water <i>via</i> ppm Au catalysis as entry to 2-substituted indoles-Reference-Cited by-同舟云学术

An environmentally responsible route to tezacaftor, a drug for treatment of cystic fibrosis prepared in water via ppm Au catalysis as entry to 2-substituted indoles

Published:2022 Issue:17 Volume:24 Page:6517-6523
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Fleck Nico¹,Thomas Rohan M.¹^ORCID,Müller Marcel²^ORCID,Grimme Stefan²^ORCID,Lipshutz Bruce H.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA-93106, USA

2. Mulliken Center for Theoretical Chemistry, University of Bonn, Beringstraße 4, 53115 Bonn, Germany

Abstract

An environmentally responsible synthesis of tezacaftor, a drug approved in 2018 currently in use for treatment of cystic fibrosis, is described utilizing chemistry in water enabled by the nonionic surfactant TPGS-750-M.

Funder

Alexander von Humboldt-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC01828D

Reference33 articles.

1. Microwave-assisted synthesis of indole- and azaindole-derivatives in water via cycloisomerization of 2-alkynylanilines and alkynylpyridinamines promoted by amines or catalytic amounts of neutral or basic salts

2. Efficient synthesis of indoles from 2-alkynylaniline derivatives in water using a recyclable copper catalyst system

3. Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium

4. Sustainable gold catalysis: synthesis of new spiroacetals

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and characterization of cis-bisdiphenylphosphinoethene gold(I) complexes;Comptes Rendus. Chimie;2024-08-27

2. Surfactant-Dependent Partitioning of Organics in Aqueous–Organic Reaction Systems;The Journal of Organic Chemistry;2024-05-16

3. API Syntheses in Aqueous Media: Assessing the Environmental Footprint en route from Academic Discovery to Industrial Applications as “Green Opportunity” for Process Chemistry;Organic Process Research & Development;2023-05-01

4. Recent advances in the synthesis of active pharmaceutical and agrochemical ingredients in micellar media;Current Opinion in Green and Sustainable Chemistry;2023-02

5. Status check: biocatalysis; its use with and without chemocatalysis. How does the fine chemicals industry view this area?;Green Chemistry;2023