The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine-Reference-Cited by-同舟云学术

The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine

Published:2016 Issue:4 Volume:5 Page:1115-1121
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Liu Xingyu¹²³,Zhang Jie¹²³,Zhang Chen¹²³,Yang Bicheng⁴⁵³,Wang Limeng⁶⁷⁸³⁹,Zhou Jun¹²³

Affiliation:

1. Shanghai Tobacco Group Corporation

2. Beijing 101121

3. China

4. Jiangxi Provincial Maternal and Child Health Hospital

5. Nanchang 330006

6. Dalian Institute of Chemical Physics

7. University of Chinese Academy of Sciences

8. Dalian 116023

9. Zhengzhou Tobacco Research Institute

Abstract

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is considered to be the most carcinogenic of the four tobacco-specific nitrosamines (TSNAs) and it needs to be metabolically activated to exert its carcinogenic effect on humans.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C6TX00016A

Reference35 articles.

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4. The occurrence of tobacco-specific nitrosamines in oral tobacco products and their potential formation under simulated gastric conditions

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