Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives-Reference-Cited by-同舟云学术

Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives

Published:2015 Issue:7 Volume:13 Page:2064-2077
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Winkler Matthias¹²³⁴⁵,Maynadier Marjorie⁶⁷⁸⁹¹⁰,Wein Sharon⁶⁷⁸⁹¹⁰,Lespinasse Marie-Ange¹²³⁴⁵,Boumis Giovanna¹¹¹²¹³¹⁴,Miele Adriana E.¹¹¹²¹³¹⁴,Vial Henri⁶⁷⁸⁹¹⁰,Wong Yung-Sing¹²³⁴⁵

Affiliation:

1. Département de Pharmacochimie Moléculaire

2. Univ. Grenoble-Alpes

3. CNRS UMR 5063

4. CNRS ICMG FR 2607

5. F-38041 Grenoble Cedex 9

6. Laboratory Dynamique des Interactions Membranaires Normales et Pathologiques

7. UMR5235

8. CNRS

9. University Montpellier 2

10. 34095 Montpellier

11. Department of Biochemical Sciences

12. “Sapienza” University of Rome

13. 00185 Rome

14. Italy

Abstract

An expedient synthesis of aculeatin-like analogues results in finding PfTrxR as putative cellular target and a promising new antimalarial chemotype.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02459A

Reference35 articles.

1. World Health Organisation. World Malaria Report 2013. http://www.who.int/malaria/media/world_malaria_report_2013/en/index.html

2. Drug-resistant malaria: Molecular mechanisms and implications for public health

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4. Antimalarial Drug Discovery: From Quinine to the Dream of Eradication

5. Natural products as starting points for future anti-malarial therapies: going back to our roots?

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