Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscopy

Author:

Placzek Fabian1234ORCID,Cordero Bautista Eliana567,Kretschmer Simon8910117,Wurster Lara M.1234,Knorr Florian567,González-Cerdas Gerardo8910117,Erkkilä Mikael T.1234,Stein Patrick8910117,Ataman Çağlar8910117,Hermann Gregers G.12131415,Mogensen Karin12131415,Hasselager Thomas16131415,Andersen Peter E.1718192015,Zappe Hans8910117,Popp Jürgen5672122,Drexler Wolfgang1234,Leitgeb Rainer A.1234,Schie Iwan W.5672324ORCID

Affiliation:

1. Center for Medical Physics and Biomedical Engineering

2. Medical University of Vienna

3. 1090 Vienna

4. Austria

5. Leibniz Institute of Photonic Technology (Leibniz-IPHT)

6. Jena

7. Germany

8. Gisela and Erwin Sick Chair of Micro-optics

9. Department of Microsystems Engineering

10. University of Freiburg

11. Freiburg

12. Department of Urology

13. Copenhagen University

14. Herlev

15. Denmark

16. Department of Pathology

17. Technical University of Denmark

18. Department of Health Technology (DTU Health Tech)

19. DK-2800

20. Kgs. Lyngby

21. Institute of Physical Chemistry

22. Friedrich Schiller University Jena

23. University of Applied Sciences-Jena

24. Department of Medical Engineering and Biotechnology

Abstract

Characterization of bladder biopsies, using a combined fiber optic probe-based optical coherence tomography and Raman spectroscopy imaging system that allows a large field-of-view imaging and detection and grading of cancerous bladder lesions.

Funder

Horizon 2020 Framework Programme

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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