Mechanistic insights into a non-heme 2-oxoglutarate-dependent ethylene-forming enzyme: selectivity of ethylene-formation versusl-Arg hydroxylation

Abstract

QM/MM calculations for a non-heme 2-oxoglutarate-dependent ethylene-forming enzyme reveal that the selectivity of ethylene formation versus succinate formation is determined by the relative energies of transition states for the competing CO₂ insertion and O–O bond cleavage of the Fe^II-peroxysuccinate species.