A general synthesis of unnatural α-amino acids by iron-catalysed olefin–olefin coupling via generated radicals

Author:

Larionov Vladimir A.12345ORCID,Stoletova Nadezhda V.123,Kovalev Vladislav I.673,Smol'yakov Alexander F.12389,Savel'yeva Tat'yana F.123,Maleev Victor I.123ORCID

Affiliation:

1. A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences

2. 119991 Moscow

3. Russian Federation

4. Department of Inorganic Chemistry

5. Peoples’ Friendship University of Russia (RUDN University)

6. Dmitry Mendeleev University of Chemical Technology of Russia

7. 125047 Moscow

8. Plekhanov Russian University of Economics

9. 117997 Moscow

Abstract

A general protocol for the asymmetric synthesis of unnatural α-amino acids with γ-tertiary and quaternary carbon centers via generated radicals is reported.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference69 articles.

1. A. B. Hughes , Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides , Wiley , Hoboken , 2013

2. V. A. Soloshonok and K.Izawa , Asymmetric Synthesis and Application of α-Amino Acids , Oxford University Press , Washington, DC , 2009

3. Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications

4. The Practice of Ring Constraint in Peptidomimetics Using Bicyclic and Polycyclic Amino Acids

5. Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis

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